External validation and clinical usefulness of first-trimester prediction models for small- and large-for-gestational-age infants: a prospective cohort study.

ABSTRACT:

Objective

To assess the external validity of all published first-trimester prediction models based on routinely collected maternal predictors for the risk of small- and large-for-gestational-age (SGA and LGA) infants. Furthermore, the clinical potential of the best-performing models was evaluated.

Design

Multicentre prospective cohort.

Setting

Thirty-six midwifery practices and six hospitals (in the Netherlands).

Population

Pregnant women were recruited at <16 weeks of gestation between 1 July 2013 and 31 December 2015.

Methods

Prediction models were systematically selected from the literature. Information on predictors was obtained by a web-based questionnaire. Birthweight centiles were corrected for gestational age, parity, fetal sex, and ethnicity.

SUBMITTER: Meertens L 

PROVIDER: S-EPMC6590121 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature