Quantitative neuroimaging measures of myelin in the healthy brain and in multiple sclerosis.

ABSTRACT: Quantitative magnetic resonance imaging (MRI) techniques have been developed as imaging biomarkers, aiming to improve the specificity of MRI to underlying pathology compared to conventional weighted MRI. For assessing the integrity of white matter (WM), myelin, in particular, several techniques have been proposed and investigated individually. However, comparisons between these methods are lacking. In this study, we compared four established myelin-sensitive MRI techniques in 56 patients with relapsing-remitting multiple sclerosis (MS) and 38 healthy controls. We used T2-relaxation with combined GRadient And Spin Echoes (GRASE) to measure myelin water fraction (MWF-G), multi-component driven equilibrium single pulse observation of T₁ and T₂ (mcDESPOT) to measure MWF-D

SUBMITTER: O'Muircheartaigh J 

PROVIDER: S-EPMC6590140 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature