Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine.

ABSTRACT: Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control, it is often necessary to rely on combination therapy of multiple drugs or insulin because uncontrolled glucose levels result in T2DM progression and enhanced risk of complications and mortality. Several antihyperglycemic agents have been developed over time, and T2DM pharmacotherapy should be prescribed based on suitability for the individual patient's characteristics. Pharmacogenetics is the branch of genetics that investigates how our genome influences individual responses to drugs, therapeutic outcomes, and incidence of adverse effects. In this review, we evaluated the pharmacogenetic evidences currently available in the literature, and we i

SUBMITTER: Mannino GC 

PROVIDER: S-EPMC6590177 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature