Association between the LIPG polymorphisms and serum lipid levels in the Maonan and Han populations.

ABSTRACT:

Introduction

The Maonan population is a relatively isolated minority in China. Little is known about endothelial lipase gene (LIPG) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese populations. The present study aimed to detect the association of several LIPG SNPs and environmental factors with serum lipid levels in the Chinese Maonan and Han populations.

Methods

In total, 773 subjects of Maonan ethnicity and 710 participants of Han ethnicity were randomly selected from our previous stratified randomized samples. Genotypes of the LIPG rs2156552, rs4939883 and rs7241918 SNPs were determined by polymerase chain reaction-restriction fragment length polymorphism, and then confirmed by direct sequencing.

Results

The allelic (rs2156552, rs4939883

SUBMITTER: Yang S 

PROVIDER: S-EPMC6590183 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature