Alteration of the intestinal flora may participate in the development of Graves' disease: a study conducted among the Han population in southwest China.

ABSTRACT:

Objectives

The pathogenesis of Graves' disease (GD) remains unclear. In terms of environmental factors, GD development may be associated with chronic inflammation caused by alteration of the intestinal flora. This study explored the association of intestinal flora alteration with the development of GD among the Han population in southwest China.

Design and methods

Fifteen GD patients at the Affiliated Hospital of Zunyi Medical College between March 2016 and March 2017 were randomly enrolled. Additionally, 15 sex- and age-matched healthy volunteers were selected as the control group during the same period. Fresh stool samples were collected, and bacterial 16S RNA was extracted and amplified for gene sequencing with the Illumina MiSeq platform. The sequencing results were subj

SUBMITTER: Yang M 

PROVIDER: S-EPMC6590206 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature