Multiparametric MR for non-invasive evaluation of tumour tissue histological characteristics after radionuclide therapy.

ABSTRACT: Early non-invasive tumour therapy response assessment requires methods sensitive to biological and physiological tumour characteristics. The aim of this study was to find and evaluate magnetic resonance imaging (MRI) derived tumour tissue parameters that correlate with histological parameters and that reflect effects of radionuclide therapy. Mice bearing a subcutaneous human small-intestine neuroendocrine tumour were i.v. injected with ¹⁷⁷ Lu-octreotate. MRI was performed (7 T Bruker Biospec) on different post-therapy intervals (1 and 13 days) using T2-weighted imaging, mapping of T2* and T1 relaxation time constants, as well as diffusion and dynamic contrast enhancement (DCE-MRI) techniques. After MRI, animals were killed and tumours excised. Four differently stained histologic

SUBMITTER: Montelius M 

PROVIDER: S-EPMC6590232 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature