Multimodal magnetic resonance imaging investigation of basal forebrain damage and cognitive deficits in Parkinson's disease.

ABSTRACT:

Background

Cognitive deficits in Parkinson's disease (PD) may result from damage in the cortex as well as in the dopaminergic, noradrenergic, and cholinergic inputs to the cortex. Cholinergic inputs to the cortex mainly originate from the basal forebrain and are clustered in several regions, called Ch1 to Ch4, that project to the hippocampus (Ch1-2), the olfactory bulb (Ch3), and the cortex and amygdala (Ch4).

Objective

We investigated changes in basal forebrain and their role in cognitive deficits in PD.

Methods

We studied 52 nondemented patients with PD (Hoehn & Yahr 1-2) and 25 age-matched healthy controls using diffusion and resting state functional MRI.

Results

PD patients had a loss of structural integrity within the Ch1-2 and Ch3-4 nuclei of the basal fo

SUBMITTER: Gargouri F 

PROVIDER: S-EPMC6590238 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature