Vedolizumab exposure levels and clinical outcomes in ulcerative colitis: determining the potential for dose optimisation.

ABSTRACT:

Background

Prospectively designed studies assessing the exposure-response profile of vedolizumab are lacking. Observational exposure-response data for vedolizumab are limited and have not been adjusted for potential confounding factors, particularly those that may affect vedolizumab clearance.

Aims

To (a) investigate the vedolizumab exposure-response relationship after adjusting for potential confounding variables; (b) propose potential target serum vedolizumab concentrations for future study; (c) ascertain whether early vedolizumab serum concentrations were associated with short- and long-term clinical outcomes in adults with ulcerative colitis in GEMINI 1.

Methods

Propensity-score-based case-matching analysis was performed using data from GEMINI 1 and an earlier lar

SUBMITTER: Osterman MT 

PROVIDER: S-EPMC6590294 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature