Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers.

ABSTRACT:

Background

Chronic constipation affects approximately 17% of the population worldwide and remains an important unmet need since patients are often dissatisfied with treatment. Kiwifruit may offer an alternative to traditional laxatives and have been shown to increase stool volume, frequency and improve consistency.

Aims

Using non-invasive MRI techniques, we assessed the effect of ingestion of kiwifruit on fluid distribution in the intestines and bowel function.

Methods

Two period crossover trial of kiwifruit vs control in healthy adults.

Intervention

two kiwifruits twice daily vs isocaloric control (maltodextrin) twice daily, consumed for a total of 3 days. Subjects underwent MRI scanning fasted and at hourly intervals for 7 hours on the third day.

Primary o

SUBMITTER: Wilkinson-Smith V 

PROVIDER: S-EPMC6590324 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature