Characterization of brain network supporting episodic memory in the absence of one medial temporal lobe.

ABSTRACT: How the brain supports normal episodic memory function without medial temporal lobe (MTL) structures has not been well characterized, which could provide clues for new therapeutic targets for people with MTL dysfunction-related memory impairment. To characterize brain network supporting effective episodic memory function in the absence of unilateral MTL, we investigated the whole-brain cortical interactions during functional magnetic resonance imaging memory encoding paradigms of words and figures in patients who showed a normal range of memory capacity following unilateral MTL resection and healthy controls (HC). Compared to the HC, the patients showed less activation in the left inferior frontal areas and right thalamus together with greater activation in the many cortical areas includin

SUBMITTER: Jeong W 

PROVIDER: S-EPMC6590340 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature