Generalizing age effects on brain structure and cognition: A two-study comparison approach.

ABSTRACT: Normal aging is accompanied by an interindividually variable decline in cognitive abilities and brain structure. This variability, in combination with methodical differences and differences in sample characteristics across studies, pose a major challenge for generalizability of results from different studies. Therefore, the current study aimed at cross-validating age-related differences in cognitive abilities and brain structure (measured using cortical thickness [CT]) in two large independent samples, each consisting of 228 healthy older adults aged between 65 and 85 years: the Longitudinal Healthy Aging Brain (LHAB) database (University of Zurich, Switzerland) and the 1000BRAINS (Research Centre Jülich, Germany). Participants from LHAB showed significantly higher education, physical well

SUBMITTER: Jockwitz C 

PROVIDER: S-EPMC6590363 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature