Comparison of nicotine exposure during pregnancy when smoking and abstinent with nicotine replacement therapy: systematic review and meta-analysis.

ABSTRACT:

Background and aims

Smoking during pregnancy is strongly associated with negative pregnancy and perinatal outcomes. Some guidelines recommend nicotine replacement therapy (NRT) for smoking cessation during pregnancy, but adherence with NRT is generally poor and could be partially explained by nicotine-related safety concerns. We compared pregnant women's cotinine and nicotine exposures from smoking with those when they were abstinent from smoking and using NRT.

Design

Systematic review with meta-analysis and narrative reporting. Twelve studies were included: in most, only one type of NRT was used. Seven were quality-assessed and judge of variable quality.

Setting

Studies from any setting that reported nicotine or cotinine levels when smoking and later when abstinent a

SUBMITTER: Hickson C 

PROVIDER: S-EPMC6590470 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature