Blockade of microglial adenosine A_2A receptor suppresses elevated pressure-induced inflammation, oxidative stress, and cell death in retinal cells.

ABSTRACT: Glaucoma is a retinal degenerative disease characterized by the loss of retinal ganglion cells and damage of the optic nerve. Recently, we demonstrated that antagonists of adenosine A_2A receptor (A_2A R) control retinal inflammation and afford protection to rat retinal cells in glaucoma models. However, the precise contribution of microglia to retinal injury was not addressed, as well as the effect of A_2A R blockade directly in microglia. Here we show that blocking microglial A_2A R prevents microglial cell response to elevated pressure and it is sufficient to protect retinal cells from elevated pressure-induced death. The A_2A R antagonist SCH 58261 or the knockdown of A_2A R expression with siRNA in microglial cells prevented

SUBMITTER: Aires ID 

PROVIDER: S-EPMC6590475 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature