Single wall and multiwall carbon nanotubes induce different toxicological responses in rat alveolar macrophages.

ABSTRACT: Human exposure to airborne carbon nanotubes (CNT) is increasing because of their applications in different sectors; therefore, they constitute a biological hazard. Consequently, developing studies on CNT toxicity become a necessity. CNTs can have different properties in term of length, size and charge. Here, we compared the cellular effect of multiwall (MWCNTs) and single wall CNTs (SWCNTs). MWCNTs consist of multiple layers of graphene, while SWCNTs are monolayers. The effects of MWCNTs and SWCNTs were evaluated by the water-soluble tetrazolium salt cell proliferation assay on NR8383 cells, rat alveolar macrophage cell line (NR8383). After 24 hours of exposure, MWCNTs showed higher toxicity (50% inhibitory concentration [IC₅₀ ] = 3.2 cm² /cm² ) than SWCNTs

SUBMITTER: Nahle S 

PROVIDER: S-EPMC6590492 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature