The COMT Val¹⁵⁸ Met polymorphism does not modulate the after-effect of tDCS on working memory.

ABSTRACT: Transcranial direct current stimulation (tDCS) can alter cortical excitability, neural plasticity, and cognitive-behavioral performance; however, its effects are known to vary across studies. A partial account of this variability relates to individual differences in dopamine function. Indeed, dopaminergic manipulations alter the physiological and cognitive-behavioral effects of tDCS, and gene polymorphisms related to dopamine have predicted individual response to online tDCS (i.e., stimulation overlapping with the critical task). Notably, the role of individual differences in dopamine has not yet been properly assessed in the effect of offline tDCS (i.e., stimulation prior to the critical task). We investigated if and how the COMT Val¹⁵⁸ Met polymorphism (rs4680) modulates the a

SUBMITTER: Jongkees BJ 

PROVIDER: S-EPMC6590637 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature