Patient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignment.

ABSTRACT:

Objective

TARGIT-A randomised women with early breast cancer to receive external beam radiotherapy (EBRT) or intraoperative radiotherapy (TARGIT-IORT). This study aimed to identify what extra risk of recurrence patients would accept for perceived benefits and risks of different radiotherapy treatments.

Methods

Patient preferences were determined by self-rated trade-off questionnaires in two studies: Stage (1) 209 TARGIT-A participants (TARGIT-IORTn = 108, EBRTn = 101); Stage (2) 123 non-trial patients yet to receive radiotherapy (pre-treatment group), with 85 also surveyed post-radiotherapy. Patients traded-off risks of local recurrence in preference selection between TARGIT-IORT and EBRT.

Results

TARGIT-IORT patients were more accepting of IORT than EBRT patients wit

SUBMITTER: Corica T 

PROVIDER: S-EPMC6590655 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature