2-Nitrobenzyl Isocyanide as a Universal Convertible Isocyanide.

ABSTRACT: 2-Nitrobenzyl isocyanide is reported as a universal convertible isocyanide with extensive applicability in both Ugi four-component reaction (Ugi-4CR) and Ugi-tetrazole reaction. The cleavage of this isocyanide from 17 examples in both acidic and basic conditions is presented. Additionally, this isocyanide has various handling and synthetic advantages, as it is easy to prepare, odorless, stable, and easy to handle as a solid.

SUBMITTER: Chandgude AL 

PROVIDER: S-EPMC6590691 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature