Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits.

ABSTRACT: The genetic architecture of psychiatric disorders is characterized by a large number of small-effect variants¹ located primarily in non-coding regions, suggesting that the underlying causal effects may influence disease risk by modulating gene expression^2-4. We provide comprehensive analyses using transcriptome data from an unprecedented collection of tissues to gain pathophysiological insights into the role of the brain, neuroendocrine factors (adrenal gland) and gastrointestinal systems (colon) in psychiatric disorders. In each tissue, we perform PrediXcan analysis and identify trait-associated genes for schizophrenia (n associations = 499; n unique genes = 275), bipolar disorder (n associations = 17; n unique genes = 13), attention deficit hyperactivity disorder (n

SUBMITTER: Gamazon ER 

PROVIDER: S-EPMC6590703 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature