Validation of a Novel Multivariate Method of Defining HIV-Associated Cognitive Impairment.

ABSTRACT:

Background

The optimum method of defining cognitive impairment in virally suppressed people living with HIV is unknown. We evaluated the relationships between cognitive impairment, including using a novel multivariate method (NMM), patient- reported outcome measures (PROMs), and neuroimaging markers of brain structure across 3 cohorts.

Methods

Differences in the prevalence of cognitive impairment, PROMs, and neuroimaging data from the COBRA, CHARTER, and POPPY cohorts (total n = 908) were determined between HIV-positive participants with and without cognitive impairment defined using the HIV-associated neurocognitive disorders (HAND), global deficit score (GDS), and NMM criteria.

Results

The prevalence of cognitive impairment varied by up to 27% between methods used t

SUBMITTER: Underwood J 

PROVIDER: S-EPMC6590980 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature