Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network.

ABSTRACT: In oscillatory systems, neuronal activity phase is often independent of network frequency. Such phase maintenance requires adjustment of synaptic input with network frequency, a relationship that we explored using the crab, Cancer borealis, pyloric network. The burst phase of pyloric neurons is relatively constant despite a > two fold variation in network frequency. We used noise input to characterize how input shape influences burst delay of a pyloric neuron, and then used dynamic clamp to examine how burst phase depends on the period, amplitude, duration, and shape of rhythmic synaptic input. Phase constancy across a range of periods required a proportional increase of synaptic duration with period. However, phase maintenance was also promoted by an increase of amplitude and peak phase o

SUBMITTER: Martinez D 

PROVIDER: S-EPMC6590986 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature