The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery.

ABSTRACT:

Rationale & objective

The process of angiogenesis after kidney injury may determine recovery and long-term outcomes. We evaluated the association of angiogenesis markers with acute kidney injury (AKI) and mortality after cardiac surgery.

Study design

Prospective cohort.

Setting & participants

1,444 adults undergoing cardiac surgery in the TRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) cohort.

Exposures

Plasma concentrations of 2 proangiogenic markers (vascular endothelial growth factor A [VEGF] and placental growth factor [PGF]) and 1 antiangiogenic marker (soluble VEGF receptor 1 [VEGFR1]), measured pre- and postoperatively within 6 hours after surgery.

Outcomes

AKI, long AKI duration (≥7 days), and 1-year a

SUBMITTER: Mansour SG 

PROVIDER: S-EPMC6591032 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature