The contribution of the locus coeruleus-norepinephrine system in the emergence of defeat-induced inflammatory priming.

ABSTRACT: Exposure to psychosocial stress is known to precipitate the emergence of stress related psychiatric disorders such as depression and anxiety. While mechanisms by which this occurs remain largely unclear, recent evidence points towards a causative role for inflammation. Neurotransmitters, such as norepinephrine (NE), are capable of regulating expression of proinflammatory cytokines and thus may contribute to the emergence of stress-related disorders. The locus coeruleus (LC) is the major source of norepinephrine (NE) to the brain and therefore the current study utilized N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), an LC selective noradrenergic neurotoxin, to determine the discrete involvement of the LC-NE system in social defeat-induced inflammation in LC projection regions includi

SUBMITTER: Finnell JE 

PROVIDER: S-EPMC6591045 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature