Body mass trajectories and cortical thickness in middle-aged men: a 42-year longitudinal study starting in young adulthood.

ABSTRACT: Evidence strongly suggests that being overweight or obese at midlife confers significantly higher risk for Alzheimer's disease and greater brain atrophy later in life. Few studies, however, examine associations between longitudinal changes in adiposity during early adulthood and later brain morphometry. Measures of body mass index (BMI) were collected in 373 men from the Vietnam Era Twin Study of Aging at average ages 20, 40, 56, and 62 years, yielding 2 BMI trajectories. We then examined associations between BMI phenotypes (trajectories, continuous BMI, obese/nonobese), cortical thickness, and white matter measures from structural magnetic resonance imaging at mean age 62 (time 4, range 56-66 years). Those on the obesity trajectory (N = 171) had a thinner cortex compared with the normal/l

SUBMITTER: Franz CE 

PROVIDER: S-EPMC6591047 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature