Hepatic Encephalopathy in Children With Acute Liver Failure: Utility of Serum Neuromarkers.

ABSTRACT:

Background

Pediatric acute liver failure (PALF) is a public heath burden, often requiring prolonged hospitalization and liver transplantation. Hepatic encephalopathy (HE) is a complication of PALF with limited diagnostic tools to predict outcomes. Serum neurological markers (neuron-specific enolase, S100β, and myelin basic protein) can be elevated in traumatic or ischemic brain injury. We hypothesized that these neuromarkers would be associated with the development of HE in PALF.

Methods

PALF study participants enrolled between May 2012 and December 2014 by 12 participating centers were the subjects of this analysis. Daily HE assessments were determined by study investigators. Neurological and inflammatory markers were measured using enzyme-linked immunosorbent assay and MIL

SUBMITTER: Toney NA 

PROVIDER: S-EPMC6591057 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature