The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2.

ABSTRACT: The protozoan parasite Toxoplasma gondii has co-evolved with its homeothermic hosts (humans included) strategies that drive its quasi-asymptomatic persistence in hosts, hence optimizing the chance of transmission to new hosts. Persistence, which starts with a small subset of parasites that escape host immune killing and colonize the so-called immune privileged tissues where they differentiate into a low replicating stage, is driven by the interleukin 12 (IL-12)-interferon-γ (IFN-γ) axis. Recent characterization of a family of Toxoplasma effectors that are delivered into the host cell, in which they rewire the host cell gene expression, has allowed the identification of regulators of the IL-12-IFN-γ axis, including repressors. We now report on the dense granule-resident effector, called TEE

SUBMITTER: Braun L 

PROVIDER: S-EPMC6591128 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature