A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex.

ABSTRACT: How the topography of neural circuits relates to their function remains unclear. Although topographic maps exist for sensory and motor variables, they are rarely observed for cognitive variables. Using calcium imaging during virtual navigation, we investigated the relationship between the anatomical organization and functional properties of grid cells, which represent a cognitive code for location during navigation. We found a substantial degree of grid cell micro-organization in mouse medial entorhinal cortex: grid cells and modules all clustered anatomically. Within a module, the layout of grid cells was a noisy two-dimensional lattice in which the anatomical distribution of grid cells largely matched their spatial tuning phases. This micro-arrangement of phases demonstrates the existenc

SUBMITTER: Gu Y 

PROVIDER: S-EPMC6591153 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature