Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies.

ABSTRACT:

Rationale

About 1.1 billion people smoke tobacco globally and tobacco-related health care costs 1.8% of GDP in many countries. The majority of people are unable to quit smoking despite pharmacological intervention, highlighting the need to understand the pathophysiology associated with tobacco smoking to aid the development of new therapeutics. The reinforcing effects of tobacco smoking are thought to be mediated by the dopamine system. However, the nature of dopamine dysfunction seen in smokers is unclear.

Objective

To determine the nature and robustness of the evidence for dopaminergic alterations in smokers.

Methods

The entire MEDLINE, EMBASE, and PsycINFO databases were searched for studies from inception date to November 18, 2018. In vivo human molecular imaging

SUBMITTER: Ashok AH 

PROVIDER: S-EPMC6591186 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature