Biomarkers for Kawasaki Disease: Clinical Utility and the Challenges Ahead.

ABSTRACT: Kawasaki disease (KD) has replaced acute rheumatic fever as the most common cause of acquired heart disease in children in the developed world and is increasingly being recognized from several developing countries. It is a systemic vasculitis with a predilection for coronary arteries. The diagnosis is based on a constellation of clinical findings that appear in a temporal sequence. Quite understandably, this can become a problem in situations wherein the clinical features are not typical. In such situations, it can be very difficult, if not impossible, to arrive at a diagnosis. Several biomarkers have been recognized in children with acute KD but none of these has reasonably high sensitivity and specificity in predicting the course of the illness. A line up of inflammatory, proteomic, gene

SUBMITTER: Chaudhary H 

PROVIDER: S-EPMC6591436 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature