Distinct Brain Regions in Physiological and Pathological Brain Aging.

ABSTRACT:

Background

Studying structural brain aging is important to understand age-related pathologies, as well as to identify the early manifestations of the Alzheimer's disease (AD) continuum. In this study, we investigated the long-term trajectory of physiological and pathological brain aging in a large number of participants ranging from the 50s to over 80 years of age.

Objective

To explore the distinct brain regions that distinguish pathological brain aging from physiological brain aging using sophisticated measurements of cortical thickness.

Methods

A total of 2,823 cognitively normal (CN) individuals and 2,675 patients with AD continuum [874 with subjective memory impairment (SMI), 954 with amnestic mild cognitive impairment (aMCI), and 847 with AD dementia] who underwe

SUBMITTER: Lee JS 

PROVIDER: S-EPMC6591468 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature