Physical Activity and Colorectal Cancer Prognosis According to Tumor-Infiltrating T Cells.

ABSTRACT:

Background

Evidence suggests that high-level physical activity may potentially reduce cancer mortality through its immune enhancement effect. We therefore hypothesized that survival benefits associated with physical activity might be stronger in colorectal carcinomas with lower immune reaction at diagnosis.

Methods

Using molecular pathological epidemiology databases of 470 colon and rectal carcinoma cases in the Nurses' Health Study and the Health Professionals Follow-up Study, we assessed the prognostic association of postdiagnosis physical activity in strata of densities of CD3⁺ cells, CD8⁺ cells, CD45RO (PTPRC)⁺ cells, or FOXP3⁺ cells in tumor tissue. Cox proportional hazards regression model was used to adjust for potential con

SUBMITTER: Koh H 

PROVIDER: S-EPMC6591576 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature