Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury.

ABSTRACT: Urinary biomarkers are superior to serum creatinine for defining onset and extent of kidney injury. This study classifies the temporal predictive ability of biomarkers for vancomycin-induced kidney injury (VIKI) as defined by histopathologic damage. Male Sprague-Dawley rats (n?=?125) were randomized to receive 150 to 400?mg/kg of body weight/day vancomycin via once or twice daily intraperitoneal injection over 1, 3, or 6?days. Urine was collected once during the 24 h prior to euthanasia or twice for rats treated for 6?days. Receiver operating characteristic (ROC) curves were employed to assess the urinary biomarker performances of kidney injury molecule 1 (KIM-1), clusterin, osteopontin (OPN), cystatin C, and neutrophil gelatinase-associated lipocalin (NGAL) to predict histopathologically defined VIKI (using a national standard pathological assessment scheme from hematoxylin and eosin stained kidneys). Urinary KIM-1, clusterin, and OPN outperformed cystatin C and NGAL with regard to sensitivity and specificity. For the earliest injury, urinary KIM-1 (area under the receiver operating characteristic curve [AUC], 0.662; P?P?

SUBMITTER: Pais GM 

PROVIDER: S-EPMC6591602 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature