Comparative Activities of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Enterobacteriaceae Isolates Producing Extended-Spectrum β-Lactamases from U.S. Hospitals.

ABSTRACT: The activities of ceftazidime-avibactam, ceftolozane-tazobactam, and comparators were evaluated for 733 isolates displaying resistance to broad-spectrum cephalosporins and carrying extended-spectrum β-lactamase (ESBL) genes detected by whole-genome sequencing analysis. Isolates were collected during 2017 in U.S. hospitals. The ESBL producers were 486 Escherichia coli, 190 Klebsiella pneumoniae, and 42 Enterobacter cloacae isolates and isolates from 3 other species. The most common groups of ESBL-encoding genes were bla_CTX-M-15-like (n = 491 isolates) and bla_CTX-M-15 alone (n = 168) or plus bla_OXA-1 (n = 260), followed by bla_CTX-M-14-like (n = 162), which included bla<

SUBMITTER: Castanheira M 

PROVIDER: S-EPMC6591606 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature