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Identification of a Carbapenemase-Producing Hypervirulent Klebsiella pneumoniae Isolate in the United States.

ABSTRACT: We report on a carbapenemase-producing hypervirulent Klebsiella pneumoniae (CP-hvKP) isolate collected from a U.S. patient at an outpatient clinic. The isolate was identified as K. pneumoniae serotype K1 sequence type 23 and included both a hypervirulence (with rmpA, rmpA2 iroBCDN, peg-344, and iucABCD-iutA genes) and a carbapenemase-encoding (bla KPC-2) plasmid. The emergence of CP-hvKP underscores the importance of clinical awareness of this pathotype and the need for continued monitoring of CP-hvKP in the United States.

SUBMITTER: Karlsson M 

PROVIDER: S-EPMC6591612 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Identification of a Carbapenemase-Producing Hypervirulent Klebsiella pneumoniae Isolate in the United States.

Karlsson Maria M   Stanton Richard A RA   Ansari Uzma U   McAllister Gillian G   Chan Monica Y MY   Sula Erisa E   Grass Julian E JE   Duffy Nadezhda N   Anacker Melissa L ML   Witwer Medora L ML   Rasheed J Kamile JK   Elkins Christopher A CA   Halpin Alison Laufer AL  

Antimicrobial agents and chemotherapy 20190624 7

We report on a carbapenemase-producing hypervirulent <i>Klebsiella pneumoniae</i> (CP-hvKP) isolate collected from a U.S. patient at an outpatient clinic. The isolate was identified as <i>K. pneumoniae</i> serotype K1 sequence type 23 and included both a hypervirulence (with <i>rmpA</i>, <i>rmpA2 iroBCDN</i>, <i>peg</i>-344, and <i>iucABCD-iutA</i> genes) and a carbapenemase-encoding (<i>bla</i><sub>KPC-2</sub>) plasmid. The emergence of CP-hvKP underscores the importance of clinical awareness o  ...[more]

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