Small vessel disease and biomarkers of endothelial dysfunction after ischaemic stroke.

ABSTRACT:

Introduction

Although pathogenesis of small vessel disease is poorly understood, increasing evidence suggests that endothelial dysfunction may have a relevant role in development and progression of small vessel disease. In this cross-sectional study, we investigated the associations between imaging signs of small vessel disease and blood biomarkers of endothelial dysfunction at two different time points in a population of ischaemic stroke patients.

Patients and methods

In stroke patients treated with intravenous thrombolysis, we analysed blood levels of von Willebrand factor, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and vascular endothelial growth factor. Three reviewers independently assessed small vessel disease features using computed tomograph

SUBMITTER: Arba F 

PROVIDER: S-EPMC6591766 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature