Rapidly disseminating bla_OXA-232 carrying Klebsiella pneumoniae belonging to ST231 in India: multiple and varied mobile genetic elements.

ABSTRACT:

Background

Recently, in India, there has been a shift from NDM to OXA48-like carbapenemases. OXA-181 and OXA-232 are the frequently produced variants of OXA48-like carbapenemases. OXA48-like carbapenemases are also known to be carried on transposons such as Tn1999, Tn1999.2 and it is also associated with IS1R carried on Tn1999. In India, there are no previous reports studying the association of mobile genetic elements (MGEs) with OXA48-like carbapenemases. The present study was aimed at determining the genetic backbone of OXA48-like carbapenemases to determine the role of MGEs in its transfer and to investigate the Inc plasmid type carrying bla_OXA48-like.

Results

A total of 49 carbapenem resistant K. pneumoniae which included 25 isolates from South India and 24 is

SUBMITTER: Shankar C 

PROVIDER: S-EPMC6591861 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature