Verification of the effects of calcium channel blockers on the immune microenvironment of breast cancer.

ABSTRACT:

Background

A higher density of tumor-infiltrating lymphocytes (TILs) can lead to greater therapeutic effects and improved prognoses in cancer treatment. Similar results have been observed in breast cancer, particularly in triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2-enriched breast cancer. Calcium channel blockers (CCBs) are antihypertensive drugs (AHTs) that have also been reported to suppress the functions of T cells and macrophages. In this study, we evaluated TILs before pre-operative chemotherapy (POC) in breast cancer and retrospectively analyzed the correlation between CCBs and TILs or prognosis.

Methods

Of the patients treated with POC, 338 who had evaluable TILs were enrolled in this study. The correlations among TILs were evalua

SUBMITTER: Takada K 

PROVIDER: S-EPMC6591916 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature