Metagenomic analysis of bile salt biotransformation in the human gut microbiome.

ABSTRACT:

Background

In the biochemical milieu of human colon, bile acids act as signaling mediators between the host and its gut microbiota. Biotransformation of primary to secondary bile acids have been known to be involved in the immune regulation of human physiology. Several 16S amplicon-based studies with inflammatory bowel disease (IBD) subjects were found to have an association with the level of fecal bile acids. However, a detailed investigation of all the bile salt biotransformation genes in the gut microbiome of healthy and IBD subjects has not been performed.

Results

Here, we report a comprehensive analysis of the bile salt biotransformation genes and their distribution at the phyla level. Based on the analysis of shotgun metagenomes, we found that the IBD subjects harbored

SUBMITTER: Das P 

PROVIDER: S-EPMC6591925 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature