Signatures of divergent anti-malarial treatment responses in peripheral blood from adults and young children in Malawi.

ABSTRACT:

Background

Heterogeneity in the immune response to parasite infection is mediated in part by differences in host genetics, gender, and age group. In infants and young children, ongoing immunological maturation often results in increased susceptibility to infection and variable responses to drug treatment, increasing the risk of complications. Even though significant age-associated effects on host cytokine responses to Plasmodium falciparum infection have been identified, age-associated effects on uncomplicated malaria infection and anti-malarial treatment remain poorly understood.

Methods

In samples of whole blood from a cohort of naturally infected malaria-positive individuals with non-severe falciparum malaria in Malawi (n = 63 total; 34 infants and young children < 2 year

SUBMITTER: Maurizio PL 

PROVIDER: S-EPMC6591936 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature