Generalizability and reproducibility of functional connectivity in autism.

ABSTRACT:

Background

Autism is hypothesized to represent a disorder of brain connectivity, yet patterns of atypical functional connectivity show marked heterogeneity across individuals.

Methods

We used a large multi-site dataset comprised of a heterogeneous population of individuals with autism and typically developing individuals to compare a number of resting-state functional connectivity features of autism. These features were also tested in a single site sample that utilized a high-temporal resolution, long-duration resting-state acquisition technique.

Results

No one method of analysis provided reproducible results across research sites, combined samples, and the high-resolution dataset. Distinct categories of functional connectivity features that differed in autism such as

SUBMITTER: King JB 

PROVIDER: S-EPMC6591952 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature