A Combination of Oxo-M and 4-PPBP as a potential regenerative therapeutics for tendon injury.

ABSTRACT: Tendons injuries frequently result in scar-like tissue with poor biochemical structure and mechanical properties. We have recently reported that CD146⁺ perivascular originated tendon stem/progenitor cells (TSCs), playing critical roles in tendon healing. Here, we identified highly efficient small molecules that selectively activate endogenous TSCs for tendon regeneration. Methods: From a pool of ERK1/2 and FAK agonists, Oxo-M and 4-PPBP were identified, and their roles in tenogenic differentiation of TSCs and in vivo tendon healing were investigated. Controlled delivery of Oxo-M and 4-PPBP was applied via PLGA µS. Signaling studies were conducted to determine the mechanism for specificity of Oxo-M and 4-PPBP to CD146⁺ TSCs. Results: A combination

SUBMITTER: Tarafder S 

PROVIDER: S-EPMC6592164 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature