PMMA-Fe₃O₄ for internal mechanical support and magnetic thermal ablation of bone tumors.

ABSTRACT: Background: Minimally invasive modalities are of great interest in the field of treating bone tumors. However, providing reliable mechanical support and fast killing of tumor cells to achieve rapid recovery of physical function is still challenging in clinical works. Methods: A material with two functions, mechanical support and magnetic thermal ablation, was developed from Fe₃O₄ nanoparticles (NPs) distributed in a polymethylmethacrylate (PMMA) bone cement. The mechanical properties and efficiency of magnetic field-induced thermal ablation were systematically and successfully evaluated in vitro and ex vivo. CT images and pathological examination were successfully applied to evaluate therapeutic efficacy with a rabbit bone tumor model. Bios

SUBMITTER: Yu K 

PROVIDER: S-EPMC6592182 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature