Influence of charged groups on the cross-linking efficiency and release of guest molecules from thiol-ene cross-linked poly(2-oxazoline) hydrogels.

ABSTRACT: We describe the preparation of hydrogels using highly functionalized poly(oxazoline) based polymeric precursors and cross-linking via UV mediated radical thiol-ene chemistry. Random copolymers were synthesized based on the combination of the more hydrophilic 2-methyl-2-oxazoline or the less hydrophilic monomer 2-ethyl-2-oxazoline with 2-(3-butenyl)-2-oxazoline. These copolymers were functionalized via a post-polymerization technique with thiol or cysteine functionality at the side chain. Hence, hydrogels were obtained, for which the thermo-responsive behavior, network density and correlated properties such as swelling and mechanics, as well as the possibility of electrostatic interaction, can be tuned. Cell culture tests demonstrated good cytocompatibility of the synthesized copolymers and

SUBMITTER: Blohbaum J 

PROVIDER: S-EPMC6592217 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature