Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study.

ABSTRACT:

Objective

To examine whether sleep traits have a causal effect on risk of breast cancer.

Design

Mendelian randomisation study.

Setting

UK Biobank prospective cohort study and Breast Cancer Association Consortium (BCAC) case-control genome-wide association study.

Participants

156 848 women in the multivariable regression and one sample mendelian randomisation (MR) analysis in UK Biobank (7784 with a breast cancer diagnosis) and 122 977 breast cancer cases and 105 974 controls from BCAC in the two sample MR analysis.

Exposures

Self reported chronotype (morning or evening preference), insomnia symptoms, and sleep duration in multivariable regression, and genetic variants robustly associated with these sleep traits.

Main outcome measure

Breast cancer

SUBMITTER: Richmond RC 

PROVIDER: S-EPMC6592406 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature