The Impact of Malaria on Liver Enzymes: A Retrospective Cohort Study (2010-2017).

ABSTRACT:

Background

It is unclear if malaria causes deranged liver enzymes. This has implications both in clinical practice and in research, particularly for antimalarial drug development.

Method

We performed a retrospective cohort study of returning travelers (n = 4548) who underwent a malaria test and had enzymes measured within 31 days in Calgary, Canada, from 2010 to 2017. Odds ratios of having an abnormal alkaline phosphatase (ALP), alanine aminotransferases (ALT), aspartate aminotransferases (AST), and total bilirubin (TB) were calculated using multivariable longitudinal analysis with binomial response.

Results

After adjusting for gender, age, and use of hepatotoxic medications, returning travelers testing positive for malaria had higher odds of having an abnormal TB (od

SUBMITTER: Cheaveau J 

PROVIDER: S-EPMC6592410 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature