Genetic changes associated with the temporal shift in invasive non-typhoidal Salmonella serovars in Bamako Mali.

ABSTRACT:

Background

Invasive non-typhoidal Salmonella (iNTS) serovars S. Typhimurium and S. Enteritidis are major etiologic agents of invasive bacterial disease among infants and young children in sub-Saharan Africa, including in Mali. Early studies of iNTS serovars in several countries indicated that S. Typhimurium was more prevalent than S. Enteritidis, including in Mali before 2008. We investigated genomic and associated phenotypic changes associated with an increase in the relative proportion of iNTS caused by S. Enteritidis versus S. Typhimurium in Bamako, Mali, during the period 2002-2012.

Methodology/principal findings

Comparative genomics studies identified homologs of tetracycline resistance and arsenic utilization genes that were associated with the temporal shift of serova

SUBMITTER: Bornstein K 

PROVIDER: S-EPMC6592554 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature