Disentangling juxtacrine from paracrine signalling in dynamic tissue.

ABSTRACT: Prolactin is a major hormone product of the pituitary gland, the central endocrine regulator. Despite its physiological importance, the cell-level mechanisms of prolactin production are not well understood. Having significantly improved the resolution of real-time-single-cell-GFP-imaging, the authors recently revealed that prolactin gene transcription is highly dynamic and stochastic yet shows space-time coordination in an intact tissue slice. However, it still remains an open question as to what kind of cellular communication mediates the observed space-time organization. To determine the type of interaction between cells we developed a statistical model. The degree of similarity between two expression time series was studied in terms of two distance measures, Euclidean and geodesic, the

SUBMITTER: Momiji H 

PROVIDER: S-EPMC6592563 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature