Transmaternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T cells.

ABSTRACT:

Background

Transmaternal exposure to tobacco, microbes, nutrients, and other environmental factors shapes the fetal immune system through epigenetic processes. The gastric microbe Helicobacter pylori represents an ancestral constituent of the human microbiota that causes gastric disorders on the one hand and is inversely associated with allergies and chronic inflammatory conditions on the other.

Objective

Here we investigate the consequences of transmaternal exposure to H pylori in utero and/or during lactation for susceptibility to viral and bacterial infection, predisposition to allergic airway inflammation, and development of immune cell populations in the lungs and lymphoid organs.

Methods

We use experimental models of house dust mite- or ovalbumin-induced airway

SUBMITTER: Kyburz A 

PROVIDER: S-EPMC6592617 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature