Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration.

ABSTRACT: Microglia from different nervous system regions are molecularly and anatomically distinct, but whether they also have different functions is unknown. We combined lineage tracing, single-cell transcriptomics, and electrophysiology of the mouse retina and showed that adult retinal microglia shared a common developmental lineage and were long-lived but resided in two distinct niches. Microglia in these niches differed in their interleukin-34 dependency and functional contribution to visual-information processing. During certain retinal-degeneration models, microglia from both pools relocated to the subretinal space, an inducible disease-associated niche that was poorly accessible to monocyte-derived cells. This microglial transition involved transcriptional reprogramming of microglia, charact

SUBMITTER: O'Koren EG 

PROVIDER: S-EPMC6592635 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature