Efficacy and Safety of Infliximab in Pediatric Crohn Disease: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Crohn disease is an inflammatory bowel disease with intermittent symptoms relating to damage to the gastrointestinal tract. Compared with adult-onset Crohn disease, the childhood-onset form is more likely to be severe. Infliximab has shown efficacy in adult patients.

Objective

To examine the efficacy and safety of infliximab in pediatric Crohn disease, by means of a systematic review.

Data sources

Three databases (MEDLINE, Embase, and Cochrane Central Register of Controlled Trials) and regulatory documents were searched from inception to December 2017. Clinical trial registries, conference abstracts, and reference lists were searched to March 2018.

Study selection and data extraction

Randomized controlled trials (RCTs) and prospective cohort studies

SUBMITTER: Li S 

PROVIDER: S-EPMC6592657 | biostudies-literature | 2019 May-Jun

REPOSITORIES: biostudies-literature