Chemical exchange saturation transfer fingerprinting for exchange rate quantification.

ABSTRACT:

Purpose

There is an increased interest to determine the exchange rate using CEST to provide pH information. However, current CEST quantification methods require lengthy scan times and do not address magnetization transfer effects. The purpose of this work was to apply the magnetic resonance fingerprinting (MRF) concept to CEST to achieve more efficient and accurate exchange rate quantification.

Methods

The proposed CEST fingerprinting method used varying saturation powers and saturation times to create unique signal evolutions for different exchange rates. The acquired signal was matched to a predefined dictionary to determine the exchange rate. The magnetization transfer effects were also addressed in the framework of CEST fingerprinting: The simulated dictionary could pred

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC6592698 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature